Throughout history, revolutionary discoveries that contradict common
knowledge have been made while searching for solutions to relatively insignificant
problems. In the 1960’s scientists were searching for the cause
of a degenerative brain disease found in sheep called scrapie. They
discovered the existence of a new infectious agent containing neither DNA
nor RNA. Later, in 1980, a neurologist named Stanley B. Prusiner
hypothesized that this new agent was a protein. Through a test, Prusiner
found his hypothesis to be true. This protein now called a Prion,
short for proteinaceous infectious particle has been found to be the cause
of degenerative brain diseases found in humans, cows, sheep and other mammals.
This discovery contradicted the common belief that DNA and RNA are the
only substances that can replicate in body tissues and it shook up the
world of biological sciences by introducing an unprecedented agent of infectious
diseases. This discovery was to have an impact not only on basic
science, but on world economics and government regulations (Encarta).
The road to the discovery began when Prusiner joined the University
of California, San Francisco in 1972. In his experiments he exposed
tissue infected with scrapie to a treatment that destroyed proteins and
found that the carrier was indeed a protein. In 1982 Prusiner and
his colleagues published their first work introducing and labeling prions.
This work talked about the fact that all animals have the gene that produces
prions, a corkscrew-shaped protein found on the outside of brain cells
(Encarta). However in an infected sheep these prions mutate from
a normal PrPC protein to a PrPSc protein and fold flat like an accordion.
When a large number of prions are infected the brain takes on a sponge-like
look (Gee, 1). The disease causes hallucinations, dementia, panic
attacks and eventually death (Schardt and Schmidt, 4).
The diseases caused by prions are called Transmissible Spongiform
Encephalopathies or TSEs. The name is derived from encephalopathy,
meaning brain, spongiform, because the diseases leave infected tissue looking
like a sponge and transmissible, because they can spread (Schardt and Schmidt,
4). In the beginning TSEs such as scrapie, found in sheep, were quite
misunderstood, and were not believed to be a threat to humans. The
only research being done was by small groups, competing over small scientific
grants for funds. It wasn’t until cows started showing symptoms much
like those of scrapie-infected sheep, that scientists started to notice.
It was decided that the cows had contracted the disease through eating
the brains of scrapie-infected sheep. Even with the discovery of
this new disease, commonly known as Mad Cow Disease or scientifically called
Bovine Spongiform Encephalopathies (BSE), scientists were not afraid that
the disease could spread to humans (Dealler, 2-4). Paul Brown at
National Institutes of Health explained that in order to infect a rat with
BSE it, “requires an injection into the brain of a thousand times more
infected tissue than it takes to give BSE to another cow. We’re counting
on this species barrier to help protect us. (Schardt and Schmidt, 5)”
The British government was insistent that humans could continue to eat
BSE infected meat because BSE could not be transmitted to humans (Dealler,
3).
There are other known TSE’s such as Creutzfeldt-Jakob disease
(CJD) and kuru, which both effect humans. There are several different
types of CJD, sporadic, genetic, iatrogenic. The sporadic type
is a spontaneous mutation of the prion gene. This accounts for nearly
eighty-five percent of all CJD cases. The genetic disease is passed
on from one generation to another. About half of a CJD carrying family
will die from the disease. The iatrogenic disease results from contact
with an infected carrier through surgery or transfusion. These three
were the only known types of CJD at the beginning of the BSE breakout (Encarta).
In 1995 a new case of CJD began showing up. Stephen Churchill
a 19-year old boy in Great Britain was the first case of variant-CJD or
V-CJD. This type of CJD is believed to have been passed from infected
cow meat to Churchill. Churchill died five months after it was first
noticed. Churchill’s father said, “I can still see his expression.
It was as if he could see what was happening but couldn’t work out how
he could stop it.” Many more would soon follow, including two more
teenagers, a 42-year-old businessman and a pregnant woman, who delivered
her baby in a coma (Scardt and Schmidt, 4-6). These incidents proved
that humans weren’t safe from “Mad Cow Disease.” After this
discovery the British government’s credibility was damaged. Throughout
the incident, government officials tried to control hysteria so that British
beef could still be exported. With this development new meat bans
were created and new regulations about beef processing were made in Great
Britain (Dealler, 2). The U.S. began taking precautions against a possible
attack of BSE or V-CJD in North America. Joe Gibbs, the acting chief
of the Laboratory of Central Nervous System Studies at the National Institutes
of Health, said, “I think it is essential for everybody to know that the
USDA (United States Department of Agriculture) is looking and we’re all
ready to jump when it happens... if it happens (Schardt and Schmidt, 6).”
In addition to beef exports, the export of blood from Great Britain might
also be banned, for it is believed that blood may carry the infectious
prion protein as well (Johnson and Gibbs, 1999). At any rate, preventive
health measures for the public and health care workers regarding blood
and brain tissue handling have changed because of prion discoveries.
The discovery of prions, the cause of BSE, CJD, kuru and scrapie,
had an impact well beyond the British beef industry and the handling of
diseased tissues. Now that the prion has been identified, it will
be much easier for a cure for all TSEs to be found. Prusiner’s discovery
might also affect the research of other neurodegenerative diseases, such
as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis
(ALS) (Encarta).
Although Prusiner’s discovery won him the 1997 Nobel Prize in
physiology or medicine, there are some scientists that would still argue
its validity. There is disagreement as to whether a virus or other
infectious agent may accompany prions, and that the prions cannot cause
infection without them. Others believe that TSEs are cause by an
unidentified slow-acting virus. Still more scientists think that
another protein, called a “chaperone,” initiates the folding of the normal
prion proteins (Dealler). Whether or not any of these theories prove
true, Prusiner’s breakthrough is invaluable for its impact on medicine,
health safety measures and perhaps most importantly the questions it has
raised for future research.
Bibliography
Dealler, Steve. History of BSE. <www.airtime.co.uk/bse/hist.htm>
(2/21/99): 1-7.
Dealler, Steve. Hypotheses for the origin and spread of BSE.
<www.airtime.co.uk/bse/hypoth.htm> (2/21/99): 1-7
Gee, Henry. Molecular Evolution of Prions. <www.mad-cow.org/~tom/prion_evol.html>
(1/11/99): 1-3.
Haywood, Anne M., M.D. “Mechanisms of Disease.” The New England
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Johnson, Richard T., M.D. and Gibbs, Clarence J., M.D. “Medical
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Schardt, David and Schmidt, Stephen. “Mad About BSE.” Nutrition
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